Antidote for tylenol toxicity4/10/2023 New simplified guidance on the treatment of acute paracetamol overdose with acetylcysteine is now in place, following an evidence-based review by the Commission on Human Medicines (CHM). After this time efficacy falls substantially, affording only a very limited window of time in which to successfully prevent serious hepatotoxicity. Intravenous acetylcysteine is the antidote to treat paracetamol overdose and is virtually 100% effective in preventing liver damage when given within 8 hours of the overdose. Paracetamol overdose can result in liver damage which may be fatal.
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